Alcoholics’ Deficits In Smell Are Linked To Frontal Lobe Dysfunction | HealtyWorld
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“We found that the alcoholics, when compared to the controls, were impaired in all three domains investigated: olfactory functions, executive function, and memory,” said Rupp. “We also found that impairments in all three domains appear resistant to early recovery after alcohol drinking stopped. Furthermore, olfactory discrimination deficits appear to be associated with executive function impairment. Collectively speaking, our results suggest that olfactory discrimination deficits and executive function impairment may share a common neural substrate - that is, a pathological process may be mediating both deficits - most likely dysfunctional mechanisms involving the frontal lobe.”
Rupp said that her findings help support the hypothesis that frontal lobes are particularly vulnerable to alcoholism-related damage, and that dysfunction in this region may play a significant role in alcoholism and other drug addictions. “Our findings add to the mounting evidence for frontal lobe dysfunction in alcoholism, which may be involved in the development of addiction, may mediate recovery in persons with alcohol-use disorders, and may play a key role in understanding the neurobiology of alcoholism,” she said.
Rupp added that her study’s findings raise some serious clinical concerns. “Olfactory dysfunction can seriously impair people in their day-to-day activities and occupation, increase their risk of injury or even death, and reduce their overall quality of life,” she said. “These deficits may not only reduce patients’ enjoyment of foods, but may also place them at risk for long term nutritional or health sequelae. Individuals may alter food choices and intake, resulting in weight loss, challenged immunity and impaired nutritional status … all of which are commonly observed in patients with chronic alcoholism. Nutritional deficiencies, moreover, also have notorious deleterious effects on brain structure and cognitive functioning. Future research needs to investigate the functional impact of olfactory dysfunction in alcohol dependence.”
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“We found that the alcoholics, when compared to the controls, were impaired in all three domains investigated: olfactory functions, executive function, and memory,” said Rupp. “We also found that impairments in all three domains appear resistant to early recovery after alcohol drinking stopped. Furthermore, olfactory discrimination deficits appear to be associated with executive function impairment. Collectively speaking, our results suggest that olfactory discrimination deficits and executive function impairment may share a common neural substrate - that is, a pathological process may be mediating both deficits - most likely dysfunctional mechanisms involving the frontal lobe.”
Rupp said that her findings help support the hypothesis that frontal lobes are particularly vulnerable to alcoholism-related damage, and that dysfunction in this region may play a significant role in alcoholism and other drug addictions. “Our findings add to the mounting evidence for frontal lobe dysfunction in alcoholism, which may be involved in the development of addiction, may mediate recovery in persons with alcohol-use disorders, and may play a key role in understanding the neurobiology of alcoholism,” she said.
Rupp added that her study’s findings raise some serious clinical concerns. “Olfactory dysfunction can seriously impair people in their day-to-day activities and occupation, increase their risk of injury or even death, and reduce their overall quality of life,” she said. “These deficits may not only reduce patients’ enjoyment of foods, but may also place them at risk for long term nutritional or health sequelae. Individuals may alter food choices and intake, resulting in weight loss, challenged immunity and impaired nutritional status … all of which are commonly observed in patients with chronic alcoholism. Nutritional deficiencies, moreover, also have notorious deleterious effects on brain structure and cognitive functioning. Future research needs to investigate the functional impact of olfactory dysfunction in alcohol dependence.”
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