New Hampshire Health News Digest

Plant-Based or Keto Diet? Novel Study Yields Surprising Results : For appetite control, a low-fat, plant-based diet has advantages over a low-carbohydrate, animal-based ketogenic diet, although the keto diet wins when it comes to keeping post-meal glucose and  insulin  levels in check, new research suggests. In a highly controlled crossover study conducted at the National Institutes of Health (NIH), people consumed fewer daily calories when on a low-fat, plant-based diet, but their insulin and blood glucose levels were higher than when they followed a low-carbohydrate, animal-based diet. "There is this somewhat outdated idea now that higher-fat diets, because they have more calories per gram, tend to make people overeat ― something called the passive overconsumption model," senior investigator Kevin Hall, PhD, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), told  Medscape Medical News . The other more popular model these days, he explained, is th...

Heart problems? A special diet might help as researchers have found that the popular and controversial ketogenic diet could completely prevent, or even reverse heart failure caused by a metabolic process. For the findings, published in the journal Nature Metabolism, the research team looked at a metabolic process that seems to be turned down in failing human hearts. "In an animal model, drastic heart failure in mice was bypassed by switching to high fat or "ketogenic" diets, which could completely prevent, or even reverse the heart failure," said study author Kyle S McCommis from the Saint Louis University in the US. "Thus, these studies suggest that consumption of higher fat and lower carbohydrate diets may be a nutritional therapeutic intervention to treat heart failure," McCommis added. According to the researchers, the heart's myocardium requires vast amounts of chemical energy stored in nutrients to fuel cardiac contraction. To maintain thi...

Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease : SIGNIFICANCE Ketogenic diet is an effective treatment for nonalcoholic fatty liver disease (NAFLD). Here, we present evidence that hepatic mitochondrial fluxes and redox state are markedly altered during ketogenic diet-induced reversal of NAFLD in humans. Ketogenic diet for 6 d markedly decreased liver fat content and hepatic insulin resistance. These changes were associated with increased net hydrolysis of liver triglycerides and decreased endogenous glucose production and serum insulin concentrations. Partitioning of fatty acids toward ketogenesis increased, which was associated with increased hepatic mitochondrial redox state and decreased hepatic citrate synthase flux. These data demonstrate heretofore undescribed adaptations underlying the reversal of NAFLD by ketogenic diet and highlight hepatic mitochondrial fluxes and redox state as potential treatment tar...

Keto diets may reverse polycystic kidney disease - Futurity KETOSIS TO FIGHT POLYCYSTIC KIDNEY DISEASE In previous studies, the research team found that reducing food intake in mouse models slowed the growth of polycystic kidneys; but at the time, they did not know why. In the new paper, the scientists identified the specific metabolic process responsible for slowing the progress of the disease. The best part? It’s a process many of us already know well. “There’s a way of avoiding the development of the cysts through dietary interventions that lead to ketosis,” Weimbs says. You read that right: Ketosis, the underlying metabolic state of popular diets such as the  ketogenic diet , and, to a lesser extent, time-restricted feeding (a form of intermittent fasting), has been shown in the Weimbs group’s studies to stall and even reverse PKD. “The cysts appear to be largely glucose-dependent,” Weimbs explains. In people with the predisposition toward PKD, the continuous supply of sugar ...

Frontiers | A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus | Frontiers in Aging Neuroscience : Age-related cognitive decline has been linked to a diverse set of neurobiological mechanisms, including bidirectional changes in proteins critical for neuron function. Importantly, these alterations are not uniform across the brain. For example, the hippocampus and prefrontal cortex show distinct patterns of dysfunction in advanced age. Because higher cognitive functions require large-scale interactions across prefrontal cortical and hippocampal networks, selectively targeting an alteration within one region may not broadly restore function to improve cognition. One mechanism for decline that the prefrontal cortex (PFC) and hippocampus (HPC) share, however, is a reduced ability to utilize glucose for energy metabolism. Although this suggests that therapeutic strategies bypassing the need for neuronal glycolysis may ...

 Reversing impaired kidney function in diabetics may be possible with the ketogenic diet. The researchers at Mount Sinai Medical School found that the ketogenic diet, a style of eating based on high-fat and low-carbohydrate intake, may be beneficial in reversing kidney function. The researchers studied mice that were genetically predisposed to have type 1 or type 2 diabetes. The mice went on to develop diabetic kidney damage. Half of the mice were put on the ketogenic diet and the other half served as controls. After eight weeks, molecular indicators of kidney damage were reversed in the mice on the ketogenic diet, along with kidney pathology in mice with type 2 diabetes. http://www.belmarrahealth.com/reversing-impaired-kidney-function-diabetics-may-possible-ketogenic-diet/

 Reversing impaired kidney function in diabetics may be possible with the ketogenic diet. The researchers at Mount Sinai Medical School found that the ketogenic diet, a style of eating based on high-fat and low-carbohydrate intake, may be beneficial in reversing kidney function. The researchers studied mice that were genetically predisposed to have type 1 or type 2 diabetes. The mice went on to develop diabetic kidney damage. Half of the mice were put on the ketogenic diet and the other half served as controls. After eight weeks, molecular indicators of kidney damage were reversed in the mice on the ketogenic diet, along with kidney pathology in mice with type 2 diabetes. http://www.belmarrahealth.com/reversing-impaired-kidney-function-diabetics-may-possible-ketogenic-diet/

 Reversing impaired kidney function in diabetics may be possible with the ketogenic diet. The researchers at Mount Sinai Medical School found that the ketogenic diet, a style of eating based on high-fat and low-carbohydrate intake, may be beneficial in reversing kidney function. The researchers studied mice that were genetically predisposed to have type 1 or type 2 diabetes. The mice went on to develop diabetic kidney damage. Half of the mice were put on the ketogenic diet and the other half served as controls. After eight weeks, molecular indicators of kidney damage were reversed in the mice on the ketogenic diet, along with kidney pathology in mice with type 2 diabetes. http://www.belmarrahealth.com/reversing-impaired-kidney-function-diabetics-may-possible-ketogenic-diet/

PLOS ONE: The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer : Ketogenic Diet alone significantly decreased blood glucose, slowed tumor growth, and increased mean survival time by 56.7% in mice with systemic metastatic cancer.

PLOS ONE: The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer : Ketogenic Diet alone significantly decreased blood glucose, slowed tumor growth, and increased mean survival time by 56.7% in mice with systemic metastatic cancer.

J Pediatr Endocrinol Metab. 2012;25(7-8):697-704. Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents. Partsalaki I, Karvela A, Spiliotis BE. BACKGROUND: The effects of carbohydrate-restricted (ketogenic) diets on metabolic parameters in children have been incompletely assessed. OBJECTIVE: To compare the efficacy and metabolic impact of ketogenic and hypocaloric diets in obese children and adolescents. SUBJECTS: Fifty-eight obese subjects were placed on one of the two diets for 6 months. METHODS: Anthropometric measurements, body composition, oral glucose/insulin tolerance test, lipidemic profile, high molecular weight (HMW) adiponectin, whole-body insulin sensitivity index (WBISI), and homeostatic model assessment-insulin resistance (HOMA-IR) were determined before and after each diet. RESULTS: Both groups significantly reduced their weight, fat mass, waist circumference, fasting insulin, and HOMA-IR (p = 0.009 for ketogenic and p = ...

Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets. Am J Clin Nutr. 2006 May;83(5):1055-61. Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets. Johnston CS, Tjonn SL, Swan PD, White A, Hutchins H, Sears B. BACKGROUND: Low-carbohydrate diets may promote greater weight loss than does the conventional low-fat, high-carbohydrate diet. OBJECTIVE: We compared weight loss and biomarker change in adults adhering to a ketogenic low-carbohydrate (KLC) diet or a nonketogenic low-carbohydrate (NLC) diet. DESIGN: Twenty adults [body mass index (in kg/m(2)): 34.4 +/- 1.0] were randomly assigned to the KLC (60% of energy as fat, beginning with approximately 5% of energy as carbohydrate) or NLC (30% of energy as fat; approximately 40% of energy as carbohydrate) diet. During the 6-wk trial, participants were sedentary, and 24-h intakes were strictly controlled. RESULTS: Mean (+/-SE) weight losses (...

Lol, this is rich. "Ketogenic Diet Reverses Kidney Disease (Nephropathy)" OMG! This is incredible! Kidney failure is irreversible! But eating this strange high fat diet COMPLETELY CURED IT within 2 months for mice! Let's start testing the diet on people whose total lack of kidney function is a death sentence, right? Wrong- quote "a high fat diet could have other problems. We don't want to actually put people on the diet, we want to figure out how the diet works and make a drug that does the same thing", Lol. Yeah,  not like kids with epilepsy have been on ketogenic diets for years since the 1950's with no ill effects. Maybe someday someone will find evidence dietary fat causes heart disease, ha ha Ketogenic Diet Reverses Kidney Disease (Nephropathy) - YouTube : Ketogenic Diet Reverses Kidney Disease (Nephropathy) Charles Mobbs, a scientist at Mount Sinai School of Medicine in New York, discovers how a low carb, ketogenic diet reverses k...

Paleolithic diets: Should we eat like our ancestors? | PCC Natural Markets By the time modern humans emerged roughly 50,000 years ago, our ancestors had adopted an omnivorous diet of cooked starches, meats (including organs), nuts, fruit and other plant foods. Although very few hunter-gatherer groups survive today, we know they eat a wide range of diets, from the nut-based diet of the African !Kung, and the palm starch diet of New Guinean hunter-gatherers, to the meat- and fat-rich diet of the Arctic Inuit. As Michael Pollan writes in "Food Rules," "There is no single, ideal human diet." Modern hunter-gatherer diets, however, tend to have certain things in common. They don't rely heavily on foods that became dominant after the development of agriculture, including dairy, grains and legumes. Starch comes from root vegetables similar to sweet potatoes, potatoes and taro. But most important, they do not eat industrial, processed foods. Other aspects of lifest...

Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets1,2,3 Carol S Johnston, Sherrie L Tjonn, Pamela D Swan, Andrea White, Heather Hutchins, and Barry Sears + Author Affiliations 1From the Department of Nutrition, Arizona State University, Mesa, AZ (CSJ, PDS, and AW); Conscious Cuisine, Scottsdale, AZ (SLT); and Inflammation Research Foundation, Marblehead, MA (HH and BS) Abstract Background:Low-carbohydrate diets may promote greater weight loss than does the conventional low-fat, high-carbohydrate diet. Objective:We compared weight loss and biomarker change in adults adhering to a ketogenic low-carbohydrate (KLC) diet or a nonketogenic low-carbohydrate (NLC) diet. Design:Twenty adults [body mass index (in kg/m2): 34.4 ± 1.0] were randomly assigned to the KLC (60% of energy as fat, beginning with ≈5% of energy as carb...

The ketogenic diet as a treatment parad - PubMed Mobile : The ketogenic diet as a treatment paradigm for diverse neurological disorders. Stafstrom CE, et al. Show all Journal Front Pharmacol. 2012;3:59. Epub 2012 Apr 9. Affiliation Department of Neurology, University of Wisconsin Madison, WI, USA. Abstract Dietary and metabolic therapies have been attempted in a wide variety of neurological diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson disease, sleep disorders, brain cancer, autism, pain, and multiple sclerosis. The impetus for using various diets to treat - or at least ameliorate symptoms of - these disorders stems from both a lack of effectiveness of pharmacological therapies, and also the intrinsic appeal of implementing a more "natural" treatment. The enormous spectrum of pathophysiological mechanisms underlying the aforementioned diseases would suggest a degree of complexity that cannot be impacted universally by any single ...

Can a High-Fat Diet Beat Cancer? By Richard Friebe The theory is simple: If most aggressive cancers rely on the fermentation of sugar for growing and dividing, then take away the sugar and they should stop spreading. Meanwhile, normal body and brain cells should be able to handle the sugar starvation; they can switch to generating energy from fatty molecules called ketone bodies — the body's main source of energy on a fat-rich diet — an ability that some or most fast-growing and invasive cancers seem to lack. The Würzburg trial, funded by the Otzberg, Germany–based diet food company Tavartis, which supplies the researchers with food packages, is still in its early, difficult stages. "One big problem we have," says Schmidt, sitting uncomfortably on a small, wooden chair in the crammed tea kitchen of Kämmerer's lab, "is that we are only allowed to enroll patients who have completely run out of all other therapeutic options." That means that most people in the ...

Epilepsy’s Big, Fat Miracle - NYTimes.com Starvation had long been one approach to treating epilepsy. Deny the patient food for, say, a week and often their seizures went away. But there were obvious limits on how long starvation could be used as a treatment. In the 1920s, researchers at the Mayo Clinic, looking for a way to treat diabetics, figured out that it was not fasting per se that helped control seizures. Rather, they found that it was what the body did during an extended fast that helped control them. Deprived of food, the human body starts burning body fat as fuel, and it was that process of ketosis that somehow had the antiepileptic effect. Trick the body into thinking it was starving by taking away its primary fuel of carbohydrates and forcing it to subsist on an all-fat diet, and you could create that antiepileptic effect as long as necessary. The diet was quickly adopted and widely used through the 1930s. And then, almost as fast as it had appeared, the keto diet disappea...

Adult obesity linked to ADHD as child - UPI.com Researchers say there's a link between childhood ADHD and adult obesity, and the greater the number of ADHD symptoms a child has the more likely they may be to be overweight in adulthood. The study looked at symptoms of inattention, hyperactivity, and impulsivity along with body mass index for 15,197 teens who were studied between 1995 and 2009. I saw a figure once that 70% of morbidly obese people have ADD. I really think there's a connection here. Scientists are beginning to learn that the brain itself can become insulin resistant. Perhaps that's why many people who do low carb or ketogenic diets to lose weight find themselves thinking more clearly, have more drive and a better mood.

Consequences of Malnutrition, Fasting, Stress and Disease - Nutrition Partner B. Braun 4. Consequences of fasting, stress and disease Fasting and stress have opposite influences on the energy expenditure of the human organism. The healthy human body is capable of passing from a state involving three regular food intakes to a state of short-term fasting and even prolonged fasting, as a result of precise metabolic regulation. In these cases, the organism will save as much energy as possible, thus reducing energy expenditure. However, in stress conditions, energy expenditure is markedly increased. As a result, the body´s metabolism will be converted into a catabolic state, the gravity of which is determined by the nature and degree of the injury and type and severity of underlying disease. These and other processes will be developed in the following chapters. [Table of contents] 4.1 Effects of fasting In theory, if a person having 15 kg of adipose triglycerides — i.e. 140.000 kcal of rese...