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Type-2 Diabetes Family History delays the onset of type 1 diabetes [PDF]

3192.pdf (application/pdf Object)

Type-1 diabetes (T1D) is an autoimmune disease leading to
insulin deficiency. Its occurrence is influenced by genetic and
environmental factors. The human leukocyte antigen (HLA)
region on chromosome 6 accounts for 45% of the genetic susceptibility
for the disease, mainly the HLA-DQB1*0201 and
HLA-DQB1*0302 alleles. Among the environmental factors involved,
early exposure to cow’s milk seems to be a trigger. In
this study, we investigated the occurrence of T1D in 253 Lebanese
Caucasian patients, in relation to HLA-DQB1*0201,
HLA-DQB1*0302, HLA-DQB1*0602, gender, and early exposure
to cow’s milk, as well as to family history of T1D and
type-2 diabetes (T2D). Our genetic analysis results show that
in the patients studied, 77% and 40% were positive for
BQ1*0201 and BQ1*0302, respectively. As for BQ1*0602, only
0.8% of patients were positive for this T1D protective allele,
compared with 24% among the controls. Furthermore, our
results did not show any gender preference of the disease or
any effects of early intake of cow’s milk on the age at onset of
T1D. When family history of T2D or T1D was studied, our
results show a novel finding whereby an immediate family
history of T2D, but not T1D, delays the age at onset of T1D.
(J Clin Endocrinol Metab 87: 3192–3196, 2002)

I have the 0602 gene that protects from type 1 diabetes.
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