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Increased adipose tissue lipolysis after a 2-week high-fat diet in sedentary overweight/obese men

Increased adipose tissue lipolysis after a 2-week high-fat diet in sedentary overweight/obese men

Increased adipose tissue lipolysis after a 2-week high-fat diet in sedentary overweight/obese men

Harold R. Howe IIIa, Kimberly Heidalb, Myung Dong Choic, Ray M. Krausc, Kristen Boylec, Robert C. HicknercdeCorresponding Author Informationemail address

Received 21 January 2010; accepted 18 September 2010. published online 01 November 2010.
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Abstract

The purpose of this study was to determine if a high-fat diet would result in a higher lipolytic rate in subcutaneous adipose tissue than a lower-fat diet in sedentary nonlean men. Six participants (healthy males; 18-40 years old; body mass index, 25-37 kg/m2) underwent 2 weeks on a high-fat or well-balanced diet of similar energy content (approximately 6695 kJ) in randomized order with a 10-day washout period between diets. Subcutaneous abdominal adipose tissue lipolysis was determined over the course of a day using microdialysis after both 2-week diet sessions. Average interstitial glycerol concentrations (index of lipolysis) as determined using microdialysis were higher after the high-fat diet (210.8 ± 27.9 μmol/L) than after a well-balanced diet (175.6 ± 23.3 μmol/L; P = .026). There was no difference in adipose tissue microvascular blood flow as determined using the microdialysis ethanol technique. These results demonstrate that healthy nonlean men who diet on the high-fat plan have a higher lipolytic rate in subcutaneous abdominal adipose tissue than when they diet on a well-balanced diet plan. This higher rate of lipolysis may result in a higher rate of fat mass loss on the high-fat diet; however, it remains to be determined if this higher lipolytic rate in men on the high-fat diet results in a more rapid net loss of triglyceride from the abdominal adipose depots, or if the higher lipolytic rate is counteracted by an increased rate of lipid storage.

Wow! Direct evidence of greater fat burning on a low carb, high fat diet.
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