Saturday, August 26, 2017
A person eating identical meals at different times of the day might deposit more fat after an evening meal than a morning meal, she said.
That’s because insulin action is more efficient in the morning, experts say. “If you give a healthy individual a big bolus of glucose in the morning, the blood glucose might stay high one or two hours before coming back to normal,” said Dr. Satchidananda Panda, a professor at the Salk Institute for Biological Studies in San Diego. “You take that same normal healthy individual and give them the same bolus of glucose late at night, and now the pancreas is sleeping — literally — and cannot produce enough insulin, and blood glucose will stay high up to three hours.” Doctors once called this “evening diabetes,” he said."
'via Blog this'
Thursday, August 03, 2017
"New research is revealing that many cases of depression are caused by an allergic reaction to inflammation. Tim de Chant of NOVA writes: “Inflammation is our immune system’s natural response to injuries, infections, or foreign compounds. When triggered, the body pumps various cells and proteins to the site through the blood stream, including cytokines, a class of proteins that facilitate intercellular communication. It also happens that people suffering from depression are loaded with cytokines.” Inflammation is caused by obesity, high sugar diets, high quantities of trans fats, unhealthy diets in general, and other causes.
By treating the inflammatory symptoms of depression — rather than the neurological ones — researchers and doctors are opening up an exciting new dimension in the fight against what has become a global epidemic. Caroline Williams of The Guardian writes: “The good news is that the few clinical trials done so far have found that adding anti-inflammatory medicines to antidepressants not only improves symptoms, it also increases the proportion of people who respond to treatment, although more trials will be needed to confirm this. There is also some evidence that omega 3 and curcumin, an extract of the spice turmeric, might have similar effects. Both are available over the counter and might be worth a try, although as an add-on to any prescribed treatment – there’s definitely not enough evidence to use them as a replacement.”"
'via Blog this'
Thursday, June 29, 2017
"Much ado has been made of the neuronal damage inflicted by aggregates of tau, but what about the cost of losing normal tau protein to these proteopathic snarls? In the June 26 Journal of Experimental Medicine, researchers led by David Blum of the University of Lille in France made the case that loss of tau function triggers insulin resistance in the brain. In tau knockout mice, hippocampal neurons responded sluggishly to insulin, laying low synaptic plasticity. Metabolic disturbances extended beyond the brain: The mice overate, were obese, and tolerated glucose poorly. The researchers proposed that loss of normal tau function in early stages of Alzheimer’s could explain the brain insulin resistance observed in some people with the disease. They claim it could even contribute to systemic metabolic disorders—such as Type 2 diabetes—that emerge prior to cognitive symptoms."
Sunday, March 19, 2017
Saturday, February 25, 2017
aClinic for Attention and Related Disorders, Yale University School of Medicine,
New Haven, Connecticut 06519, USA
bCalifornia Pacific Epilepsy Center, San Francisco, California 94115, USA
ABSTRACT: Many children, adolescents, and adults with Attention Deficit Disorders
report chronic difficulties with falling asleep, awakening and/or maintaining
adequate daytime alertness. These problems may be due to a variety of
factors, including environment, lifestyle, and psychiatric comorbidities.
Impairments in sleep/arousal may also be related more directly to the underlying
pathophysiology of ADD. This chapter describes clinical manifestations
of sleep/arousal problems often associated with ADD and reviews behavioral
and medication options for treatment.
KEYWORDS: ADD; ADHD; Sleep disturbances; Sleep disorders.
"Given the above, it is not surprising that a fair degree of overlap exists between
these two disorders, though the rates of sleep disturbance in children with attention
deficit/hyperactivity disorder (ADHD) is much higher than one would expect even
given the high prevalence of sleep problems in the general school-age cohort. Ball
9 have reported that more than 50% of children with ADHD have difficulty falling
asleep. Stein10 reported that moderate to severe sleep problems occurred at least
once a week in nearly 20% of children with ADHD compared to 13.3% of psychiatric
controls, and 6.2% of pediatric controls."
Adolescent and adult patients too may suffer from inadequate wind-down routines
to prepare for sleep or from ruminative worry, or from evening family conflicts.
Some report that they remain awake primarily due to becoming distracted by activity
that is inconsistent with sleep (reading, surfing the internet, socializing). For some it
is actually easier to concentrate in the evening when background environmental
stimulation may be reduced relative to the targeted activity. Attempts at daytime
attention to target material may be thwarted by frequent interruption by distracting
background activity, while evening activity is both more stimulating than sleep (e.g.,
it is the distractor), and less often interrupted by competing stimuli. These patients
sometimes are able to fall asleep when they so engage, but establish behavior patterns
over time that preclude adequate sleep. Others may attempt to self medicate
sleep disturbance by using over the counter sleep aids or alcohol. These attempts are
often less than effective because they may not work, they may contribute to exacerbation
of attention problems, and they may alter the quality of sleep attained.25,26
Attention to proper sleep hygiene (discussed later in this chapter) and avoidance of
potentially maladaptive behavior patterns may offer some relief from problems falling
asleep in these patients.
Other patients with ADD report a lifelong pattern of consistently becoming more
alert in the evening, feeling more energized and more ready to engage in work or
social activities after dark than in the daytime. These individuals often describe a
pattern of difficulty falling asleep until very late at night; as preschoolers they may
not have been able to settle and fall into sleep until 10 or 11 P.M. most nights. As
adolescents or adults they may chronically feel restless and unable to sleep until 2 or
274 ANNALS NEW YORK ACADEMY OF SCIENCES
3 A.M. or later. Attention to proper sleep hygiene may help these patients, but they
may continue to experience delayed onset of sleep due to internal restlessness, even
in the absence of maladaptive behavioral patterns.
At present, it is not clear how these problems in getting to sleep are related to the
pathophysiology of ADD. Dahl has emphasized that there is a strong relationship
between the control of sleep and the regulation of mood and behavior in waking
states, yet he notes that “Our current knowledge of these complex relationships
between sleep, development and psychiatric well-being is at an embryonic state.”17
These issues are discussed later in this chapter
Sunday, February 19, 2017
The interaction between nutrition and the brain and its consequences for body weight gain and metabolism; studies in rodents and men. - PubMed - NCBI
The interaction between nutrition and the brain and its consequences for body weight gain and metabolism; studies in rodents and men.
la Fleur SE1, Serlie MJ2.
Aberrant feeding behavior can lead to obesity and obesity-related medical consequences, such as insulin resistance and diabetes. Although alterations in glucose metabolism (i.e. insulin resistance), in the presence of excessive fat tissue are often explained by the consequences of dysfunctional adipose tissue, evidence is emerging that also altered brain functions might be an important determinant of insulin resistance. In this review, we provide an overview of how feeding behavior and obesity interact with brain circuitry and how these interactions affect glucose metabolism. Because brain circuitries involved in food intake have been shown to partly control glucose metabolism as well, targeting these circuitries in obese subjects might not only affect food intake and body weight but also glucose metabolism.
Wednesday, February 08, 2017
Kravitz AV1, O'Neal TJ2, Friend DM2.
Obesity is associated with physical inactivity, which exacerbates the negative health consequences of obesity. Despite a wide consensus that people with obesity should exercise more, there are few effective methods for increasing physical activity in people with obesity. This lack is reflected in our limited understanding of the cellular and molecular causes of physical inactivity in obesity. We hypothesize that impairments in dopamine signaling contribute to physical inactivity in people with obesity, as in classic movement disorders such as Parkinson's disease. Here, we review two lines of evidence supporting this hypothesis: (1) chronic exposure to obesogenic diets has been linked to impairments in dopamine synthesis, release, and receptor function, particularly in the striatum, and (2) striatal dopamine is necessary for the proper control of movement. Identifying the biological determinants of physical inactivity may lead to more effective strategies for increasing physical activity in people with obesity, as well as improve our understanding of why it is difficult for people with obesity to alter their levels of physical activity.
Saturday, February 04, 2017
Thursday, January 26, 2017
An article published in BMC Psychiatry this week shows that zinc supplements could increase the effectiveness of stimulants used to treat children with attention deficit hyperactivity disorder (ADHD).
"The effects of ADHD on individual children differ, but symptoms include inattention, hyperactivity and impulsiveness. Stimulants are the most common treatment prescribed, but recent findings that vitamin and mineral deficiencies correlate with ADHD suggest that dietary supplements could also play a role in disease management.