Frontiers | A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus | Frontiers in Aging Neuroscience
Frontiers | A ketogenic diet improves cognition and has biochemical effects in prefrontal cortex that are dissociable from hippocampus | Frontiers in Aging Neuroscience : Age-related cognitive decline has been linked to a diverse set of neurobiological mechanisms, including bidirectional changes in proteins critical for neuron function. Importantly, these alterations are not uniform across the brain. For example, the hippocampus and prefrontal cortex show distinct patterns of dysfunction in advanced age. Because higher cognitive functions require large-scale interactions across prefrontal cortical and hippocampal networks, selectively targeting an alteration within one region may not broadly restore function to improve cognition. One mechanism for decline that the prefrontal cortex (PFC) and hippocampus (HPC) share, however, is a reduced ability to utilize glucose for energy metabolism. Although this suggests that therapeutic strategies bypassing the need for neuronal glycolysis may