Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype Nicholas G Norwitz, David Feldman, Adrian Soto-Mota, Tro Kalayjian, David S Ludwig Current Developments in Nutrition, Volume 6, Issue 1, January 2022, nzab144, https://doi.org/10.1093/cdn/nzab144 Published: 30 November 2021 Article history Fit people have greater LDL increase doing low carb, if I'm reading this correctly? ABSTRACT Background People commencing a carbohydrate-restricted diet (CRD) experience markedly heterogenous responses in LDL cholesterol, ranging from extreme elevations to reductions. Objectives The aim was to elucidate possible sources of heterogeneity in LDL cholesterol response to a CRD and thereby identify individuals who may be at risk for LDL cholesterol elevation. Methods Hypothesis-naive analyses were conducted on web survey data from 548 adults consuming a CRD. Univariate and multivariate regression models and regression trees were buil...