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Nerve changes from diabetes begin earlier than previously known

0905 Di Nerve changes from diabetes begin earlier than previously known

Nerve changes from diabetes begin earlier than previously known

Mayo Clinic research reinforces the importance of blood sugar control from onset of diabetes to prevent nerve damage later

ROCHESTER, Minn. (Sep - 2005) -- Mayo Clinic researchers have found that subtle change in nerve conduction is the first reliable sign of nerve complications from diabetes and that this change can be measured long before other symptoms or signs of nerve damage develop.

"We've found what we believe is the earliest sign of nerve change due to diabetes," says Peter J. Dyck, M.D., Mayo Clinic neurologist and lead researcher on the study. Results were published in the September issue of Diabetes Care. "Changes begin much earlier than previously demonstrated," he says.

About 500 patients from Olmsted County, Minn., home to Mayo Clinic, participated in the longitudinal study, many for 20 years. Patients agreed to periodic measures of their diabetes and measurement of nerve, eye, kidney and blood vessel complications.

About half the people with diabetes develop some type of nerve damage (neuropathy) caused indirectly by high blood sugar levels. Symptoms can include pain, asleep-type numbness, tingling, burning and loss of feeling. Serious complications can include foot ulcers, gangrene, amputations, blindness and kidney failure.

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