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Physical Inactivity Rapidly Induces Insulin Resistance and Microvascular Dysfunction in Healthy Volunteers -- Hamburg et al. 27 (12): 2650 -- Arterios

Physical Inactivity Rapidly Induces Insulin Resistance and Microvascular Dysfunction in Healthy Volunteers -- Hamburg et al. 27 (12): 2650 -- Arteriosclerosis, Thrombosis, and Vascular Biology

Conclusions— Physical inactivity was associated with the development of insulin resistance, dyslipidemia, increased blood pressure, and impaired microvascular function in healthy volunteers. Our findings may provide insight into the pathogenesis of vascular disease in sedentary individuals and emphasize that even short-term physical inactivity may have adverse metabolic and vascular consequences.

Physical inactivity is associated with cardiovascular disease. We examined the effect of 5 days of bed rest on insulin resistance and vascular function in healthy subjects. Bed rest induced vascular dysfunction, insulin resistance, dyslipidemia, and increased blood pressure. Our findings provide insight into the pathogenesis of vascular disease in sedentary individuals.
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