Dopamine and Insulin Resistance - Full Text View - ClinicalTrials.gov:
"Obese individuals have fewer striatal dopamine type 2 receptors (DRD2) than normal weight individuals. Lower DRD2 levels are associated with addiction and a decreased sense of pleasure. Obesity is also associated with insulin resistance (poor insulin action); however approximately 10% of obese adults are metabolically healthy and do not have insulin resistance. We propose that insulin resistance contributes to low dopamine type 2 receptors and, using PET imaging, aim to determine if DRD2 binding in the brain and insulin resistance correlate."