Friday, November 19, 2010

Dietary Sugar and Mental Illness: A Surprising Link | Psychology Today

Dietary Sugar and Mental Illness: A Surprising Link | Psychology Today

Dietary Sugar and Mental Illness: A Surprising Link
Sugar and Mental Illness: A Surprising Link
Published on July 23, 2009

Noted British psychiatric researcher Malcolm Peet has conducted a provocative cross-cultural analysis of the relationship between diet and mental illness. His primary finding may surprise you: a strong link between high sugar consumption and the risk of both depression and schizophrenia.

In fact, there are two potential mechanisms through which refined sugar intake could exert a toxic effect on mental health.

First, sugar actually suppresses activity of a key growth hormone in the brain called BDNF. This hormone promotes the health and maintenance of neurons in the brain, and it plays a vital role in memory function by triggering the growth of new connections between neurons. BDNF levels are critically low in both depression and schizophrenia, which explains why both syndromes often lead to shrinkage of key brain regions over time (yes, chronic depression actually leads to brain damage). There's also evidence from animal models that low BDNF can trigger depression.

Second, sugar consumption triggers a cascade of chemical reactions in the body that promote chronic inflammation. Now, under certain circumstances (like when your body needs to heal a bug bite), a little inflammation can be a good thing, since it can increase immune activity and blood flow to a wound. But in the long term, inflammation is a big problem. It disrupts the normal functioning of the immune system, and wreaks havoc on the brain.

Inflammation is associated with an increased risk of heart disease, diabetes, arthritis, and even some forms of cancer . . . it's also linked to a greater risk of depression and schizophrenia. And again, eating refined sugar triggers inflammation. So does eating heavily processed molecular cousins like 'high fructose corn syrup'.

Not surprising to me, ha ha! I've seen a good amount of evidence for this. Something as simple as sugar can have so many different effects in different people. It may be hard for people to believe that my obesity, Fred's depression, Mary's arthritis, and Joe's schizophrenia can all be traced to refined carbs, but the evidence is there. I read some interesting stuff a while back about "insulin shock" therapy. They gave people hyperdoses of insulin, putting them into a diabetic coma. Then later they would wake them up with a glucose injection. Sometimes it worked. One of the most famous people treated was physicist John Nash, portrayed by Russell Crowe in the movie A Beautiful Mind. Seems to me as if there's a connection between the insulin/sugar process and schizophrenia for some people. There's also evidence that cannabis use in susceptible users may encourage the development of schizophrenia. I'm not sure how solid that link is, and if it's based on simple correlation observed in epidemiological studies, which would not necessarily imply causation. But if there is a link, I wonder about the fact that some report that using cannibis can affect blood sugar, I believe by lowering it acutely, leading to the munchies. Speculation, but again, I like looking for links.

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