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Interacting Effects of the Dopamine Transporter Gene and Psychosocial Adversity on Attention-Deficit/Hyperactivity Di

Arch Gen Psychiatry -- Abstract: Interacting Effects of the Dopamine Transporter Gene and Psychosocial Adversity on Attention-Deficit/Hyperactivity Disorder Symptoms Among 15-Year-Olds From a High-Risk Community Sample, May 2007, Laucht et al. 64 (5): 585

Interacting Effects of the Dopamine Transporter Gene and Psychosocial Adversity on Attention-Deficit/Hyperactivity Disorder Symptoms Among 15-Year-Olds From a High-Risk Community Sample

Manfred Laucht, PhD; Markus H. Skowronek, PhD; Katja Becker, MD; Martin H. Schmidt, MD, PhD; Günter Esser, PhD; Thomas G. Schulze, MD; Marcella Rietschel, MD

Arch Gen Psychiatry. 2007;64:585-590.

Context Recent evidence suggests that gene x environment interactions could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with attention-deficit/hyperactivity disorder (ADHD).

So there's a gene for ADHD, but not everyone with the gene (allele 10 variant of the VNTR 40 base pair DAT gene) gets ADHD. They studied a bunch of kids and found that kids with the gene AND ADHD had some family stressors. So you need the gene, and environmental stress to develop ADHD. I would imagine that physical stresses, like a mother smoking while pregnant (a risk factor for ADHD) could also have the same effect). Or not getting enough sleep. I finally got a good nights sleep last night and I feel fantastic today! I should sleep 18 hours every day!
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