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eMedicine - Dopamine-Responsive Dystonia : Article by N K Nikhar, MD

eMedicine - Dopamine-Responsive Dystonia : Article by N K Nikhar, MD: "The activity of these dopaminergic neurons also has circadian variation. Dopamine production increases through the night with each cycle of rapid eye movement (REM) sleep. The activity at the nigrostriatal terminals is therefore maximal in the early morning; nocturnal variation is more marked in young children and decreases with age. Dopamine activity in nigrostriatal terminals, which already is reduced in patients with DRD, declines further during the course of the day (as well as with increasing age), exacerbating symptoms toward evening and with increasing age."

Very interesting. I know that dopamine deficiency is implicated in ADD, and ADD'ers have trouble sleeping. Less sleep could mean less dopamine in the brain.
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