ScienceDaily: Researchers Determine That MS And Diabetes Are Closely Linked Diseases
Science Daily — Toronto, March 20, 2001 - A team of researchers led by Hospital for Sick Children (HSC) senior scientist Michael Dosch has determined that multiple sclerosis and type I (juvenile) diabetes mellitus are far more closely linked than previously thought, including the role cow milk protein plays as a risk factor in the development of both diseases for people who are genetically susceptible. This research is published in recent issues of The Journal of Immunology (April 1 and February 15, 2001).
Multiple sclerosis (MS) and type I diabetes mellitus are autoimmune disorders, where the body's immune system attacks its own tissue. The diseases are entirely different clinically, but have nearly identical ethnic and geographic distribution, genetic similarities, and, as is now known, shared environmental risk factors.
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"Much to our surprise, we found that immunologically, type I diabetes and multiple sclerosis are almost the same - in a test tube you can barely tell the two diseases apart," said Dr. Dosch, the study's principal investigator, a senior scientist in the HSC Research Institute, and a professor of Paediatrics and Immunology at the University of Toronto (U of T). "We found that the autoimmunity was not specific to the organ system affected by the disease. Previously it was thought that in MS autoimmunity would develop in the central nervous system, and in diabetes it would only be found in the pancreas. We found that both tissues are targeted in each disease."
In diabetes and MS, there is a long, drawn-out period of silent disease years before the appearance of symptoms and diagnosis of the disease. In diabetes, it is this "pre-diabetes" phase that is targeted by interventions to stop the development of the full-blown disease. Similar efforts are planned for individuals at high risk for MS.
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One of the major environmental risk factors for diabetes is exposure to cow milk protein. Based on the role of cow milk protein as a risk factor in the development of type I diabetes, an international global diabetes prevention trial called TRIGR - Trial to Reduce Insulin-dependent diabetes in the Genetically at Risk - is expected to begin later this year, with Dr. Dosch as the trial's basic science chair. In the first step to test just how far the similarities between MS and diabetes go, the study's researchers looked for signs of abnormal immunity to cow milk in MS patients. Such abnormalities were indeed found in most patients, suggesting that similar processes may contribute to both diseases. If confirmed in a larger and prospective family study, it may become possible to design dietary means to influence the course of MS as well as diabetes.
Cow's milk is an unnatural food, like grains. Our ancestors did not eat these foods, because we need technology to process these foods. (agriculture or animal husbandry). These foods provoke a potent autoimmune response from our bodies, causing most of the "diseases of civilization", from arthritis, diabetes, MS, Parkinson's, heart disease, obesity, etc.
Science Daily — Toronto, March 20, 2001 - A team of researchers led by Hospital for Sick Children (HSC) senior scientist Michael Dosch has determined that multiple sclerosis and type I (juvenile) diabetes mellitus are far more closely linked than previously thought, including the role cow milk protein plays as a risk factor in the development of both diseases for people who are genetically susceptible. This research is published in recent issues of The Journal of Immunology (April 1 and February 15, 2001).
Multiple sclerosis (MS) and type I diabetes mellitus are autoimmune disorders, where the body's immune system attacks its own tissue. The diseases are entirely different clinically, but have nearly identical ethnic and geographic distribution, genetic similarities, and, as is now known, shared environmental risk factors.
[...]
"Much to our surprise, we found that immunologically, type I diabetes and multiple sclerosis are almost the same - in a test tube you can barely tell the two diseases apart," said Dr. Dosch, the study's principal investigator, a senior scientist in the HSC Research Institute, and a professor of Paediatrics and Immunology at the University of Toronto (U of T). "We found that the autoimmunity was not specific to the organ system affected by the disease. Previously it was thought that in MS autoimmunity would develop in the central nervous system, and in diabetes it would only be found in the pancreas. We found that both tissues are targeted in each disease."
In diabetes and MS, there is a long, drawn-out period of silent disease years before the appearance of symptoms and diagnosis of the disease. In diabetes, it is this "pre-diabetes" phase that is targeted by interventions to stop the development of the full-blown disease. Similar efforts are planned for individuals at high risk for MS.
[...]
One of the major environmental risk factors for diabetes is exposure to cow milk protein. Based on the role of cow milk protein as a risk factor in the development of type I diabetes, an international global diabetes prevention trial called TRIGR - Trial to Reduce Insulin-dependent diabetes in the Genetically at Risk - is expected to begin later this year, with Dr. Dosch as the trial's basic science chair. In the first step to test just how far the similarities between MS and diabetes go, the study's researchers looked for signs of abnormal immunity to cow milk in MS patients. Such abnormalities were indeed found in most patients, suggesting that similar processes may contribute to both diseases. If confirmed in a larger and prospective family study, it may become possible to design dietary means to influence the course of MS as well as diabetes.
Cow's milk is an unnatural food, like grains. Our ancestors did not eat these foods, because we need technology to process these foods. (agriculture or animal husbandry). These foods provoke a potent autoimmune response from our bodies, causing most of the "diseases of civilization", from arthritis, diabetes, MS, Parkinson's, heart disease, obesity, etc.
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