Too much sugar turns off gene that controls the effects of sex steroids
High levels of sugar in your bloodstream can turn off the gene that controls your sex hormones.
The simple sugars, glucose and fructose, are metabolized in your liver, with the excess stored as fat lipids. Excess fat synthesis deactivates your SHBG (sex hormone binding globulin) gene, causing your levels of SHBG protein to drop dramatically, and it is this SHBG protein that controls your testosterone and estrogen levels.
Too little SHBG protein means your body will produce too much testosterone and estrogen, which increases your chances of acne, infertility, polycystic ovaries, uterine cancer, and heart disease.
Said Dr. Geoffrey Hammond, lead researcher, “We discovered that low levels of SHBG in a person’s blood means the liver’s metabolic rate is out of whack – because of inappropriate diet or something that ‘s inherently wrong with the liver – long before there are any disease symptoms.”
This new study also challenges the previous conventional thought that high levels of insulin are to blame for the drop in SHBG, and that it’s actually the liver’s metabolism of sugar that counts.