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Case report: The combined use of amantadine and l-dopa/ carbidopa in the treatment of chronic brain injury - Brain Injury

Case report: The combined use of amantadine and l-dopa/ carbidopa in the treatment of chronic brain injury - Brain Injury

Abstract
The frontal lobes are particularly vulnerable to injury during trauma. The syndrome commonly attributed to frontal lobe dysfunction includes problems with impulsivity, perseveration, disinhibition, amotivation, attention, planning, and problem solving. These symptoms can respond to certain phar macologic interventions, such as the dopaminergic agents. The case of a 50 year old woman who showed persistent frontal dysfunction 5 years post injury is described. After treatment with amantadine alone, she showed decreased impulsivity and perseveration and improved executive function. Further positive response was obtained with the addition of l dopa carbidopa, with additional improvements in constructional praxis, divided auditory attention, and cognitive flexibility. Her improved function ing following treatment demonstrates the potential for increasing effectiveness through a combination of dopaminergic agents. No side effects were observed, and the patient maintained gains at follow up. The rationale for using dopaminergic agents alone and in combination is discussed.

This drug, Amantadine, appears to be an anti-viral drug used to treat frontal lobe dysfunction, as in ADD. I want to find out more about it.
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