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Emotion-based decision-making in healthy subjects: short-term effects of reducing dopamine levels

SpringerLink - Journal Article

Emotion-based decision-making in healthy subjects: short-term effects of reducing dopamine levels

Abstract
Introduction

Converging evidences from animal and human studies suggest that addiction is associated with dopaminergic dysfunction in brain reward circuits. So far, it is unclear what aspects of addictive behaviors are related to a dopaminergic dysfunction.
Discussion We hypothesize that a decrease in dopaminergic activity impairs emotion-based decision-making.

[...]

Our results suggest a direct link between a reduced dopaminergic activity and poor emotion-based decision-making characterized by shortsightedness, and thus difficulties resisting short-term reward, despite long-term negative consequences. These findings have implications for behavioral and pharmacological interventions targeting impaired emotion-based decision-making in addictive disorders.
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